GHRP-6
GHRP-6
Also known as: GHRP-6, Growth Hormone Releasing Hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Overview
Key Facts
Primary Goal: A synthetic hexapeptide that potently stimulates growth hormone release via the ghrelin receptor (GHS-R1a)
A synthetic hexapeptide that potently stimulates growth hormone release via the ghrelin receptor (GHS-R1a). GHRP-6 is included in the sleep category because it significantly amplifies the nocturnal GH surge that occurs during deep sleep. Unlike Ipamorelin, GHRP-6 also strongly stimulates appetite and has broader hormonal effects (including cortisol and prolactin elevation), making it more suitable for individuals seeking both sleep enhancement and anabolic/recovery support. Half-Life ~15-60 minutes Typical Dose 100–300 mcg Frequency Once daily before bedtime, or 2-3 times daily Cycle Length 8-12 weeks on, 4 weeks off
Dosing Information
Half-Life
~15-60 minutes
Typical Dose
100–300 mcg
Frequency
Once daily before bedtime, or 2-3 times daily
Cycle Length
8-12 weeks on, 4 weeks off
Administration Routes:
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Note: Protect from light. Do not freeze reconstituted solution.
Research Summary
GHRP-6 was one of the first synthetic GH secretagogues studied, with extensive research dating to the 1980s by Bowers et al. Clinical studies demonstrated dose-dependent GH release 5-10 times above baseline, with peak levels at 15-30 minutes mail-injection. Sleep studies (Frieboes et al., 1995) showed that GH secretagogues significantly increase slow-wave sleep and nocturnal GH amplitude. Unlike Ipamorelin, GHRP-6 also elevates cortisol and prolactin, which limits its selectivity. Its strong appetite stimulation is mediated through the same ghrelin receptor pathway and can be beneficial or problematic depending on the individual's goals.
Frequently Asked Questions
Common questions about GHRP-6
UK-Specific Information
Exclusive data points and guidance for UK residents using GHRP-6
UK Lab Testing
US Lab Testing
Recommended labs: Quest Diagnostics, LabCorp ($120-$200 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
Commonly Stacked With
Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.