Ac-SDKP
Ac-SDKP
Also known as: Thymosin Beta-4 Fragment Ac-SDKP, Goralatide, Seraspenide
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Ac-SDKP
Inhibits TGF-β/Smad signaling to prevent fibrosis. Blocks connective tissue growth factor (CTGF) expression.
Dosing Information
~5 minutes (rapidly cleaved by ACE)
100–400 mcg
1x daily
4-8 weeks
Benefits
- Potent antifibrotic effects in heart, kidney, and liver
- Inhibits collagen deposition in fibrotic tissue
- Anti-inflammatory properties
- Regulates hematopoietic stem cell proliferation
- Cardioprotective effects post-myocardial infarction
Side Effects
Mechanism of Action
Inhibits TGF-β/Smad signaling to prevent fibrosis
Blocks connective tissue growth factor (CTGF) expression
Reduces inflammatory cell infiltration in damaged tissues
Prevents epithelial-to-mesenchymal transition (EMT)
Endogenously maintained by ACE inhibitor therapy (elevated in ACEi users)
Contraindications
Do not use this peptide if any of the following apply:
- Concurrent ACE inhibitor use (synergistic elevation may be excessive)
- Severe hypotension
- Pregnancy or breastfeeding
- Active bleeding disorders
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Studied extensively in animal models of cardiac, renal, and hepatic fibrosis with consistent antifibrotic results. Its role as the endogenous substrate of ACE partly explains the antifibrotic benefits of ACE inhibitors. Phase 1 human data exists from hematopoietic studies (Goralatide/Seraspenide).
Frequently Asked Questions
Common questions about Ac-SDKP
UK-Specific Information
Exclusive data points and guidance for UK residents using Ac-SDKP
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
Commonly Stacked With
5-Amino-1MQ
Research and therapeutic applications of 5-Amino-1MQ
ACE-031
Research and therapeutic applications of ACE-031
Acetyl Hexapeptide-3
Research and therapeutic applications of Acetyl Hexapeptide-3
AHK-Cu
Research and therapeutic applications of AHK-Cu
Alcohol Prep Pads
Research and therapeutic applications of Alcohol Prep Pads
AOD-9604
Research and therapeutic applications of AOD-9604
Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
Share on TikTok
Generate a trackable link to share this peptide information on TikTok