Epitalon
Epitalon
Also known as: Epithalon, Epithalone, AGAG, Ala-Glu-Asp-Gly
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Epitalon
Stimulates pinealocytes to restore melatonin synthesis and secretion. Reactivates genes involved in circadian clock regulation.
Dosing Information
~2-3 hours
5–10 mg
Once daily for 10-20 day cycles
10-20 days on, 4-6 months off
Benefits
- Restores age-depleted melatonin production for natural sleep regulation
- Normalizes circadian rhythm in elderly individuals
- Activates telomerase to lengthen telomeres (anti-ageing crossover)
- Improves sleep onset and sleep quality through pineal gland support
- Supports immune function and neuroendocrine balance
Side Effects
Mechanism of Action
Stimulates pinealocytes to restore melatonin synthesis and secretion
Reactivates genes involved in circadian clock regulation
Activates telomerase enzyme (hTERT) for anti-ageing effects
Enhances antioxidant defence enzymes (SOD, catalase) to reduce oxidative sleep disruption
Contraindications
Do not use this peptide if any of the following apply:
- Active cancer (telomerase activation could theoretically promote tumour growth)
- Autoimmune conditions without medical supervision
- Pregnancy or breastfeeding
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. A key study in elderly patients (ages 60-80) demonstrated that Epitalon restored evening melatonin peaks to levels resembling those of younger adults, with corresponding improvements in sleep quality and daytime alertness. The 15-year longitudinal study showed improved immune function, cardiovascular health, and endocrine balance alongside the sleep benefits. Its dual role in melatonin restoration and telomere elongation makes it uniquely positioned among sleep-supportive peptides.
Frequently Asked Questions
Common questions about Epitalon
UK-Specific Information
Exclusive data points and guidance for UK residents using Epitalon
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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