FOXO4-DRI
FOXO4-DRI
Also known as: FOXO4-DRI Senolytic, Proxofim
Overview
Key Facts
Primary Goal: Research and therapeutic applications of FOXO4-DRI
Disrupts the FOXO4-p53 interaction that keeps senescent cells alive. Liberates p53 to trigger mitochondrial apoptosis in senescent cells.
Dosing Information
~12-24 hours (estimated due to D-amino acid stability)
5–20 mg
Twice weekly for defined cycles
2-4 weeks on, extended rest periods (months)
Benefits
- Selective elimination of senescent (zombie) cells
- Reversal of age-related tissue dysfunction in animal models
- Restored fur density and kidney function in aged mice
- Potential to reduce chronic inflammation from senescent cell burden
Side Effects
Mechanism of Action
Disrupts the FOXO4-p53 interaction that keeps senescent cells alive
Liberates p53 to trigger mitochondrial apoptosis in senescent cells
Selectively targets cells with high FOXO4 nuclear localisation (senescent phenotype)
Contraindications
Do not use this peptide if any of the following apply:
- Active cancer or pre-cancerous conditions
- Immunocompromised individuals
- Pregnancy or breastfeeding
- No human safety profile established
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Published in Cell (2017) by de Keizer et al., FOXO4-DRI demonstrated selective clearance of senescent cells in naturally aged mice, resulting in restored fitness, fur density, and renal function. The D-retro-inverso design confers protease resistance and improved bioavailability. While one of the most scientifically compelling senolytic approaches, it remains strictly in preclinical research with no human trials completed. Its large size and synthesis complexity make it one of the most expensive research peptides.
Frequently Asked Questions
Common questions about FOXO4-DRI
UK-Specific Information
Exclusive data points and guidance for UK residents using FOXO4-DRI
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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