Glutathione
Glutathione
Also known as: GSH, Reduced Glutathione, L-Glutathione, Master Antioxidant
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Glutathione
Directly scavenges free radicals and reactive oxygen/nitrogen species. Serves as cofactor for glutathione peroxidase and glutathione S-transferase enzymes.
Dosing Information
~10-15 minutes (IV); intracellular GSH persists for hours
200–600 mg
1-3x per week (injectable) or daily (oral/liposomal)
Continuous supplementation or 8-12 week cycles
Benefits
- Master antioxidant — neutralizes reactive oxygen species and free radicals
- Essential for Phase II liver detoxification of drugs and environmental toxins
- Supports immune cell function (T-cells, NK cells, macrophages)
- Skin brightening and reduction of hyperpigmentation (inhibits melanin synthesis)
- Protects mitochondria from oxidative damage
- Regenerates other antioxidants (Vitamin C, Vitamin E)
- Supports lung health and respiratory function
Side Effects
Mechanism of Action
Directly scavenges free radicals and reactive oxygen/nitrogen species
Serves as cofactor for glutathione peroxidase and glutathione S-transferase enzymes
Conjugates toxins, heavy metals, and drug metabolites for biliary/renal excretion
Inhibits tyrosinase enzyme activity, reducing melanin production
Maintains redox homeostasis to support mitochondrial membrane integrity
Recycles oxidized Vitamin C and Vitamin E back to their active forms
Contraindications
Do not use this peptide if any of the following apply:
- Asthma (inhaled glutathione may trigger bronchospasm — injectable is fine)
- Concurrent chemotherapy (may interfere with pro-oxidant drug mechanisms — consult oncologist)
- Pregnancy or breastfeeding (injectable; oral supplementation generally considered safe)
- Known allergy to glutathione or any excipient
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Glutathione is one of the most researched molecules in biology, with over 170,000 PubMed-indexed publications. Clinical studies have demonstrated its role in Parkinson's disease (IV glutathione improved motor scores in pilot trials), non-alcoholic fatty liver disease (NAFLD), cystic fibrosis, and HIV/AIDS-related immune decline. Dermatological research confirms its skin-lightening effects, with a randomized controlled trial in the Journal of Clinical and Aesthetic Dermatology showing significant improvement in melanin index after 4 weeks of oral supplementation. The poor oral bioavailability of standard GSH has driven innovation in liposomal, sublingual, and injectable delivery methods.
Frequently Asked Questions
Common questions about Glutathione
UK-Specific Information
Exclusive data points and guidance for UK residents using Glutathione
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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