Humanin
Humanin
Also known as: HN, HNG, S14G-Humanin, Mitochondrial-Derived Peptide
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Humanin
Binds to IGFBP-3 to block BAX-mediated mitochondrial apoptosis. Activates STAT3 signaling pathway for cell survival.
Dosing Information
~30 minutes (native); enhanced analogs (HNG) have longer duration
1–5 mg
Once daily or 3-5 times per week
4-8 weeks on, 4 weeks off
Benefits
- Potent neuroprotective effects against amyloid-beta toxicity
- Cytoprotective against oxidative stress and apoptosis
- Improved insulin sensitivity and metabolic regulation
- Cardiovascular protection against ischemia-reperfusion injury
- Supports mitochondrial function and cellular resilience
Side Effects
Mechanism of Action
Binds to IGFBP-3 to block BAX-mediated mitochondrial apoptosis
Activates STAT3 signaling pathway for cell survival
Interacts with formyl peptide receptors to reduce inflammation
Protects mitochondrial membrane integrity under stress conditions
Contraindications
Do not use this peptide if any of the following apply:
- Active cancer (anti-apoptotic effects could theoretically promote tumour survival)
- Pregnancy or breastfeeding
- No established human safety profile
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Discovered in 2001 by Bhshimoto et al. during research on Alzheimer's disease, humanin has since been shown to have broad cytoprotective effects. The S14G analog (HNG) is 1000x more potent than native humanin. Studies show that circulating humanin levels decline with age and correlate with Alzheimer's risk, mitochondrial dysfunction, and metabolic disease. Animal studies demonstrate protection against atherosclerosis, diabetes, and neurodegeneration. Epidemiological data from centenarian studies (led by Dr. Pinchas Cohen at USC) show elevated humanin levels in exceptionally long-lived individuals.
Frequently Asked Questions
Common questions about Humanin
UK-Specific Information
Exclusive data points and guidance for UK residents using Humanin
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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