IGF-2
IGF-2
Also known as: IGF-II, Somatomedin A
Overview
Key Facts
Primary Goal: Research and therapeutic applications of IGF-2
Binds IGF-1 receptor to activate PI3K/Akt and MAPK/ERK pathways. Binds insulin receptor isoform A (IR-A), particularly relevant in muscle progenitor cells.
Dosing Information
~15 minutes (heavily regulated by IGFBPs and IGF-2R clearance)
20–100 mcg
Once daily (research dosing, not clinically established)
4-8 weeks (research context only)
Benefits
- Supports satellite cell self-renewal maintaining the stem cell pool
- Promotes myogenic differentiation during muscle regeneration
- May enhance muscle recovery without depleting satellite cell reserves
- Potential role in connective tissue repair and bone healing
- Complementary to IGF-1 with distinct regenerative signaling kinetics
Side Effects
Mechanism of Action
Binds IGF-1 receptor to activate PI3K/Akt and MAPK/ERK pathways
Binds insulin receptor isoform A (IR-A), particularly relevant in muscle progenitor cells
Promotes asymmetric satellite cell division, maintaining the stem cell niche while generating committed myoblasts
Cleared by IGF-2R (mannose-6-phosphate receptor) which directs it to lysosomes
Regulated by imprinting — loss of imprinting (LOI) is associated with pathological overgrowth
Contraindications
Do not use this peptide if any of the following apply:
- Active malignancy or history of IGF-2-overexpressing tumours
- Beckwith-Wiedemann syndrome or other imprinting disorders
- Diabetes or insulin-dependent conditions
- Pregnancy or breastfeeding
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
IGF-2 has been studied primarily in developmental biology and cancer research. Seminal work by Merrick et al. demonstrated IGF-2's role in satellite cell self-renewal during muscle regeneration in mice. Unlike IGF-1, which drives differentiation, IGF-2 maintains the regenerative capacity of the satellite cell pool. While preclinical evidence is promising for muscle repair applications, no clinical trials for musculoskeletal indications exist. Its complex regulation through genomic imprinting adds a layer of biological nuance absent in other IGF family peptides.
Frequently Asked Questions
Common questions about IGF-2
UK-Specific Information
Exclusive data points and guidance for UK residents using IGF-2
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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