What is the half-life of Kisspeptin-10?

Kisspeptin-10 has a half-life of Unknown, which is why it's typically administered As needed for optimal therapeutic effect.

How do I reconstitute Kisspeptin-10?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

What is the half-life of Kisspeptin-10?

Kisspeptin-10 has a half-life of Unknown, which is why it's typically administered As needed for optimal therapeutic effect.

How do I reconstitute Kisspeptin-10?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Phase 1

Kisspeptin-10

Also known as: KP-10, Metastin 45-54, Kisspeptin

Overview

Key Facts

Primary Goal: Research and therapeutic applications of Kisspeptin-10

Binds KISS1R (GPR54) on GnRH neurons in the hypothalamic arcuate nucleus, triggering GnRH pulse secretion. Downstream GnRH release stimulates anterior pituitary gonadotrophs to secrete LH and FSH.

Dosing Information

Half-Life

~4 minutes (IV bolus); ~28 minutes (SC)

Typical Dose

1–10 mcg

Frequency

single dose or pulsatile infusion in research protocols

Cycle Length

Research protocols vary; typically acute or short-term dosing

Administration Routes:

subcutaneousintravenous

Benefits

Potent stimulator of endogenous LH and FSH release
Restores pulsatile GnRH secretion in hypothalamic amenorrhea
Enhances sexual arousal and brain limbic activity in neuroimaging studies
May improve reproductive function in both sexes
Acts as a physiological regulator rather than pharmacological override

Side Effects

Mild facial flushinguncommonmild

Transient lower abdominal warmthuncommonmild

Injection site discomfortuncommonmild

Potential ovarian hyperstimulation in women (in clinical settings)uncommonmild

Mechanism of Action

Binds KISS1R (GPR54) on GnRH neurons in the hypothalamic arcuate nucleus, triggering GnRH pulse secretion

Downstream GnRH release stimulates anterior pituitary gonadotrophs to secrete LH and FSH

Activates limbic brain regions (amygdala, cingulate cortex) associated with sexual arousal and emotional processing

Contraindications

Do not use this peptide if any of the following apply:

Hormone-sensitive malignancies (breast, prostate)
Pregnancy or breastfeeding
Pituitary tumours or disorders

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Phase 1

Kisspeptin-10 has been studied in multiple Phase I/II clinical trials at Imperial College London and other institutions. Research demonstrates it potently stimulates LH secretion in healthy volunteers and can restore reproductive hormone pulsatility in women with hypothalamic amenorrhea. Functional MRI studies have shown kisspeptin enhances brain processing of sexual and romantic stimuli, suggesting a role beyond pure endocrine regulation. It is being investigated as a potential therapeutic for infertility and low sexual desire.

Frequently Asked Questions

Common questions about Kisspeptin-10

UK-Specific Information

Exclusive data points and guidance for UK residents using Kisspeptin-10

UK Lab Testing

Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)

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