KPV
KPV
Also known as: KPV Tripeptide, Alpha-MSH Fragment 11-13
Overview
Key Facts
Primary Goal: Research and therapeutic applications of KPV
Inhibits NF-kB nuclear translocation and activation. Reduces pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β).
Dosing Information
~30 minutes
200–500 mcg
1-2x daily
4-12 weeks
Benefits
- Potent anti-inflammatory without immunosuppression
- Supports gut lining repair and reduces intestinal inflammation
- Antimicrobial properties against bacteria and fungi
- May improve skin conditions (eczema, psoriasis)
- Crosses the blood-brain barrier for neuroinflammation
Side Effects
Mechanism of Action
Inhibits NF-kB nuclear translocation and activation
Reduces pro-inflammatory cytokine production (TNF-α, IL-6, IL-1β)
Modulates inflammasome pathways
Directly enters intestinal epithelial cells to reduce inflammation
Exhibits direct antimicrobial activity on cell membranes
Contraindications
Do not use this peptide if any of the following apply:
- Pregnancy or breastfeeding
- Autoimmune conditions (consult physician)
- Active immunosuppressive therapy
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Studied primarily in preclinical models of colitis, skin inflammation, and infection. Demonstrated ability to reduce intestinal inflammation in IBD mouse models comparable to standard treatments. Strong in vitro evidence for NF-kB pathway inhibition.
Frequently Asked Questions
Common questions about KPV
UK-Specific Information
Exclusive data points and guidance for UK residents using KPV
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
Commonly Stacked With
5-Amino-1MQ
Research and therapeutic applications of 5-Amino-1MQ
Ac-SDKP
Research and therapeutic applications of Ac-SDKP
ACE-031
Research and therapeutic applications of ACE-031
Acetyl Hexapeptide-3
Research and therapeutic applications of Acetyl Hexapeptide-3
AHK-Cu
Research and therapeutic applications of AHK-Cu
Alcohol Prep Pads
Research and therapeutic applications of Alcohol Prep Pads
Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
Share on TikTok
Generate a trackable link to share this peptide information on TikTok