LL-37
LL-37
Also known as: Cathelicidin, hCAP-18 Fragment, CAMP
Overview
Key Facts
Primary Goal: Research and therapeutic applications of LL-37
Directly disrupts microbial cell membranes via amphipathic alpha-helix insertion. Inhibits bacterial biofilm matrix formation and promotes dispersal.
Dosing Information
~4 hours
50–100 mcg
1x daily or every other day
4-8 weeks
Benefits
- Broad-spectrum antimicrobial activity (bacteria, fungi, viruses)
- Disrupts bacterial biofilm formation
- Promotes wound healing and angiogenesis
- Neutralizes bacterial endotoxin (LPS)
- Recruits immune cells to infection sites (chemotactic)
- Modulates adaptive immune response activation
Side Effects
Mechanism of Action
Directly disrupts microbial cell membranes via amphipathic alpha-helix insertion
Inhibits bacterial biofilm matrix formation and promotes dispersal
Activates formyl peptide receptor-like 1 (FPRL1) for immune cell chemotaxis
Stimulates TLR-mediated immune signaling in macrophages and dendritic cells
Promotes keratinocyte migration and re-epithelialization in wounds
Contraindications
Do not use this peptide if any of the following apply:
- Active rosacea or psoriasis (LL-37 overexpression implicated)
- Pregnancy or breastfeeding
- Known hypersensitivity to cathelicidin peptides
- Active autoimmune skin conditions
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Extensively studied innate immune peptide with over 2,000 published papers. Phase 1 clinical trials conducted for chronic wound healing (OP-145, a derivative). Strong preclinical data for biofilm-associated infections, diabetic wound healing, and adjunct antibiotic therapy. Vitamin D-dependent expression explains some immune benefits of vitamin D supplementation.
Frequently Asked Questions
Common questions about LL-37
UK-Specific Information
Exclusive data points and guidance for UK residents using LL-37
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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