MGF
MGF
Also known as: Mechano Growth Factor, IGF-1Ec, MGF peptide
Overview
Key Facts
Primary Goal: Research and therapeutic applications of MGF
Unique E-domain peptide activates quiescent satellite (stem) cells in damaged muscle. Initiates satellite cell proliferation before they differentiate (priming phase).
Dosing Information
5-7 minutes (extremely short, rapidly degraded by proteases)
100–400 mcg
Immediately post-workout, bilaterally into trained muscle groups
4-5 weeks
Benefits
- Activates dormant satellite cells to initiate muscle repair
- Promotes local muscle-specific hypertrophy at injection site
- Complements the later-acting systemic IGF-1 isoforms
- May enhance recovery from acute muscle injury
- Does not significantly impact systemic IGF-1 or insulin levels
Side Effects
Mechanism of Action
Unique E-domain peptide activates quiescent satellite (stem) cells in damaged muscle
Initiates satellite cell proliferation before they differentiate (priming phase)
Acts in an autocrine/paracrine manner within mechanically stressed muscle tissue
Signals through the IGF-1 receptor but with distinct downstream signaling kinetics due to E-domain
Contraindications
Do not use this peptide if any of the following apply:
- Active malignancy
- Pregnancy or breastfeeding
- Acute muscle tears (may worsen inflammation acutely)
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
MGF was discovered by Dr. Geoffrey Goldspink's group at University College London. Research demonstrated that mechanical overload induces MGF expression as the initial IGF-1 splice variant before shifting to IGF-1Ea (systemic). Animal studies show MGF administration increases muscle mass by 20% within weeks. The extremely short half-life of the synthetic peptide limits practical use, leading to the development of PEG-MGF for extended activity.
Frequently Asked Questions
Common questions about MGF
UK-Specific Information
Exclusive data points and guidance for UK residents using MGF
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
Commonly Stacked With
5-Amino-1MQ
Research and therapeutic applications of 5-Amino-1MQ
Ac-SDKP
Research and therapeutic applications of Ac-SDKP
ACE-031
Research and therapeutic applications of ACE-031
Acetyl Hexapeptide-3
Research and therapeutic applications of Acetyl Hexapeptide-3
AHK-Cu
Research and therapeutic applications of AHK-Cu
Alcohol Prep Pads
Research and therapeutic applications of Alcohol Prep Pads
Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
Share on TikTok
Generate a trackable link to share this peptide information on TikTok