NAD+
NAD+
Also known as: NAD, Coenzyme NAD, Nicotinamide Adenine Dinucleotide
Overview
Key Facts
Primary Goal: Research and therapeutic applications of NAD+
Serves as essential substrate for sirtuin deacetylases (SIRT1-7) regulating gene expression. Fuels PARP enzymes for DNA single-strand break repair.
Dosing Information
~30-45 minutes (IV); tissue levels persist longer
50–200 mg
1-3x per week (subcutaneous) or 250-500 mg IV
Continuous supplementation or 4-12 week cycles
Benefits
- Activates sirtuins (SIRT1-7) for DNA repair and longevity pathways
- Restores mitochondrial function and ATP production
- Enhances cellular energy metabolism
- Supports cognitive function and neuroprotection
- Promotes DNA damage repair via PARP enzymes
- Improves metabolic health and insulin sensitivity
- May support healthy circadian rhythm regulation
Side Effects
Mechanism of Action
Serves as essential substrate for sirtuin deacetylases (SIRT1-7) regulating gene expression
Fuels PARP enzymes for DNA single-strand break repair
Acts as electron carrier in mitochondrial oxidative phosphorylation (Complex I)
Regulates CD38/NADase activity in immune and inflammatory signaling
Supports circadian clock gene expression via SIRT1-CLOCK interactions
Contraindications
Do not use this peptide if any of the following apply:
- Active cancer (NAD+ may fuel rapidly dividing cells — consult oncologist)
- Gout or hyperuricemia (NAD+ metabolism can elevate uric acid)
- Pregnancy or breastfeeding
- Caution with concurrent chemotherapy or immunotherapy
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
NAD+ biology has exploded in research interest since the work of David Sinclair (Harvard) and Shin-ichiro Imai (Washington University) on sirtuins and ageing. Human studies have demonstrated that NAD+ precursors (NMN and NR) safely elevate blood NAD+ levels. Clinical trials show improvements in insulin sensitivity, muscle function in elderly subjects, and cardiovascular biomarkers. IV NAD+ is widely used in integrative medicine clinics for energy, cognitive support, and addiction recovery, though large-scale RCTs for the injectable form are still limited. The compound is central to the 'Information Theory of Ageing' proposed by Sinclair's lab.
Frequently Asked Questions
Common questions about NAD+
UK-Specific Information
Exclusive data points and guidance for UK residents using NAD+
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Alcohol Prep Pads
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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