Palmitoyl Tripeptide-1
Palmitoyl Tripeptide-1
Also known as: Pal-GHK, Biopeptide-CL, Palmitoyl Oligopeptide
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Palmitoyl Tripeptide-1
GHK sequence acts as a matrikine, mimicking collagen degradation fragments. Activates TGF-beta signaling to upregulate collagen gene transcription.
Dosing Information
~3-5 hours (topical bioactivity window)
2–5 mg
Twice daily (topical application)
Continuous daily use; visible results at 8-12 weeks
Benefits
- Stimulates collagen I and III production in dermal fibroblasts
- Reduces wrinkle depth and skin roughness
- Improves skin tone and luminosity
- Enhances extracellular matrix repair signaling
- Synergistic with Palmitoyl Tetrapeptide-7 (as Matrixyl 3000)
- Well-tolerated with minimal irritation potential
Side Effects
Mechanism of Action
GHK sequence acts as a matrikine, mimicking collagen degradation fragments
Activates TGF-beta signaling to upregulate collagen gene transcription
Palmitoyl group enhances stratum corneum penetration for improved dermal delivery
Stimulates fibroblast proliferation and glycosaminoglycan synthesis
Synergizes with anti-inflammatory peptides to reduce inflammaging
Contraindications
Do not use this peptide if any of the following apply:
- Known allergy to any component
- Severely compromised skin barrier (open wounds, active infections)
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Palmitoyl Tripeptide-1 was developed as a biomimetic signaling peptide based on the naturally occurring GHK sequence. In vitro studies demonstrated significant upregulation of collagen I and III synthesis in human dermal fibroblasts. When combined with Palmitoyl Tetrapeptide-7 (as Matrixyl 3000, developed by Sederma), clinical studies showed synergistic wrinkle reduction superior to either peptide alone. A 12-week study demonstrated up to 44% reduction in wrinkle volume. It is widely incorporated in premium anti-ageing skincare products.
Frequently Asked Questions
Common questions about Palmitoyl Tripeptide-1
UK-Specific Information
Exclusive data points and guidance for UK residents using Palmitoyl Tripeptide-1
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
Commonly Stacked With
5-Amino-1MQ
Research and therapeutic applications of 5-Amino-1MQ
Ac-SDKP
Research and therapeutic applications of Ac-SDKP
ACE-031
Research and therapeutic applications of ACE-031
Acetyl Hexapeptide-3
Research and therapeutic applications of Acetyl Hexapeptide-3
AHK-Cu
Research and therapeutic applications of AHK-Cu
Alcohol Prep Pads
Research and therapeutic applications of Alcohol Prep Pads
Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
Share on TikTok
Generate a trackable link to share this peptide information on TikTok