Selank
Selank
Also known as: Selank, TP-7, Selanc
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Selank
Allosteric modulation of GABA-A receptors to enhance inhibitory neurotransmission without benzodiazepine-like sedation. Inhibits enkephalin-degrading enzymes, prolonging endogenous anxiolytic opioid signaling.
Dosing Information
~3-5 minutes (native); active metabolites persist for several hours
250–750 mcg
1-3 times daily; evening dose for sleep support
2-4 weeks on, 2 weeks off
Benefits
- Reduces anxiety that causes insomnia and sleep-onset difficulty
- Modulates GABA system without sedation, tolerance, or dependence
- Improves sleep quality in stress-related and anxiety-driven insomnia
- Enhances cognitive function and memory consolidation during sleep
- Stabilizes mood and emotional regulation
- Immunomodulatory effects supporting overall health
Side Effects
Mechanism of Action
Allosteric modulation of GABA-A receptors to enhance inhibitory neurotransmission without benzodiazepine-like sedation
Inhibits enkephalin-degrading enzymes, prolonging endogenous anxiolytic opioid signaling
Modulates serotonin (5-HT) and dopamine metabolism for mood stabilization
Influences BDNF expression for neuroprotection and synaptic plasticity
Activates IL-6 and T-helper cell pathways for immune modulation (tuftsin analog activity)
Contraindications
Do not use this peptide if any of the following apply:
- Concurrent use of benzodiazepines or strong GABAergic drugs (potential interaction)
- Active autoimmune conditions (immunomodulatory effects may be unpredictable)
- Pregnancy or breastfeeding
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Selank has been approved in Russia as an anxiolytic medication (nasal spray formulation) and has been studied in over 30 clinical and preclinical trials. Studies demonstrated anxiolytic effects comparable to benzodiazepines but without sedation, cognitive impairment, or dependence. Zozulia et al. showed that Selank normalized the sleep-wake cycle in patients with generalized anxiety disorder, with improvements in both sleep onset latency and sleep maintenance. Gene expression studies revealed modulation of 45 genes related to GABAergic and serotonergic neurotransmission. Its dual anxiolytic-nootropic profile makes it particularly valuable for individuals whose sleep disturbance stems from anxiety or cognitive hyperarousal.
Frequently Asked Questions
Common questions about Selank
UK-Specific Information
Exclusive data points and guidance for UK residents using Selank
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
Commonly Stacked With
5-Amino-1MQ
Research and therapeutic applications of 5-Amino-1MQ
Ac-SDKP
Research and therapeutic applications of Ac-SDKP
ACE-031
Research and therapeutic applications of ACE-031
Acetyl Hexapeptide-3
Research and therapeutic applications of Acetyl Hexapeptide-3
AHK-Cu
Research and therapeutic applications of AHK-Cu
Alcohol Prep Pads
Research and therapeutic applications of Alcohol Prep Pads
Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
Share on TikTok
Generate a trackable link to share this peptide information on TikTok