SS-31 (Elamipretide)
SS-31 (Elamipretide)
Also known as: Elamipretide, MTP-131, Bendavia, NAD+ Precursor Peptide
Overview
Key Facts
Primary Goal: Research and therapeutic applications of SS-31 (Elamipretide)
Binds cardiolipin in the inner mitochondrial membrane to stabilize electron transport complexes. Reduces mitochondrial reactive oxygen species (ROS) production.
Dosing Information
~4 hours
0.25–4 mg
Once daily
4-12 weeks as studied in clinical trials
Benefits
- Restores mitochondrial function and energy production
- Reduces oxidative stress at the mitochondrial level
- Improves cardiac and skeletal muscle performance
- Protects against age-related cellular decline
- Supports kidney function in mitochondrial diseases
Side Effects
Mechanism of Action
Binds cardiolipin in the inner mitochondrial membrane to stabilize electron transport complexes
Reduces mitochondrial reactive oxygen species (ROS) production
Restores ATP synthesis and mitochondrial membrane potential
Prevents cardiolipin peroxidation to maintain cristae structure
Contraindications
Do not use this peptide if any of the following apply:
- Severe renal impairment (use with monitoring)
- Pregnancy or breastfeeding
- Known hypersensitivity to peptide components
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Developed by Stealth BioTherapeutics, elamipretide has been evaluated in multiple Phase 2 and 3 clinical trials. The TAZPOWER trial in Barth syndrome showed improvements in six-minute walk test distance. Studies in primary mitochondrial myopathy (MMPOWER) and heart failure (PROGRESS-HF) have shown mixed results, though biomarker improvements were noted. Preclinical data strongly support mitochondrial protection against age-related decline, ischemia-reperfusion injury, and neurodegenerative conditions.
Frequently Asked Questions
Common questions about SS-31 (Elamipretide)
UK-Specific Information
Exclusive data points and guidance for UK residents using SS-31 (Elamipretide)
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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