Triptorelin
Triptorelin
Also known as: GnRH Agonist, Trelstar, Decapeptyl, Diphereline, Triptorelin Pamoate
Overview
Key Facts
Primary Goal: Research and therapeutic applications of Triptorelin
D-Trp6 substitution makes the peptide resistant to enzymatic cleavage, increasing potency ~100-fold over native GnRH. Acute administration causes a flare: robust release of LH and FSH from pituitary gonadotrophs.
Dosing Information
~3 hours (immediate release); depot formulations provide sustained release over weeks
100–200 mcg
single dose or as prescribed (depot formulations monthly/quarterly)
Single dose in PCT protocols; months to years in clinical applications
Benefits
- FDA-approved for prostate cancer, endometriosis, and precocious puberty
- Single low-dose protocol researched for post-cycle testosterone recovery
- Potent stimulation of LH/FSH during initial flare phase
- Long-acting depot formulations available for clinical use
Side Effects
Mechanism of Action
D-Trp6 substitution makes the peptide resistant to enzymatic cleavage, increasing potency ~100-fold over native GnRH
Acute administration causes a flare: robust release of LH and FSH from pituitary gonadotrophs
Chronic continuous exposure downregulates and desensitizes GnRH receptors, suppressing LH, FSH, and downstream sex steroids
Contraindications
Do not use this peptide if any of the following apply:
- Pregnancy (Category X)
- Known hypersensitivity to GnRH or GnRH analogs
- Undiagnosed vaginal bleeding
- Osteoporosis or significant bone density loss
Storage & Reconstitution
Unreconstituted (Powder)
Reconstituted (Mixed)
Research Summary
Triptorelin is FDA-approved under multiple brand names (Trelstar, Decapeptyl) for advanced prostate cancer, endometriosis, and central precocious puberty. In the peptide research community, it has gained interest due to a small 2009 study by Tan & Scally suggesting that a single low-dose (100 mcg) injection could significantly stimulate endogenous testosterone recovery after anabolic steroid-induced hypogonadism. While this application remains under-studied, the compound's clinical pharmacology is well-established.
Frequently Asked Questions
Common questions about Triptorelin
UK-Specific Information
Exclusive data points and guidance for UK residents using Triptorelin
UK Lab Testing
UK Lab Testing
Recommended labs: Medichecks, Thriva (£89-£149 for peptide safety panel)
Why this matters: UK-specific lab testing guidance not available on US competitor sites
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Note: Peptide stacking should only be done under the guidance of a qualified healthcare professional. Individual responses may vary.
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