What is the half-life of Ac-SDKP?

Ac-SDKP has a half-life of ~5 minutes (rapidly cleaved by ACE), which is why it's typically administered 1x daily for optimal therapeutic effect.

How do I reconstitute Ac-SDKP?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Phase 2

Ac-SDKP

Also known as: Thymosin Beta-4 Fragment Ac-SDKP, Goralatide, Seraspenide

Overview

Key Facts

Primary Goal: A tetrapeptide naturally released from Thymosin Beta-4 by prolyl oligopeptidase

A tetrapeptide naturally released from Thymosin Beta-4 by prolyl oligopeptidase. Acts as a potent endogenous antifibrotic agent and is normally present in human plasma and urine. Hydrolyzed by ACE. Half-Life ~5 minutes (rapidly cleaved by ACE) Typical Dose 100–400 mcg Frequency 1x daily Cycle Length 4-8 weeks

Dosing Information

Half-Life

~5 minutes (rapidly cleaved by ACE)

Typical Dose

100–400 mcg

Frequency

1x daily

Cycle Length

4-8 weeks

Administration Routes:

subcutaneousintravenous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Phase 2

Studied extensively in animal models of cardiac, renal, and hepatic fibrosis with consistent antifibrotic results. Its role as the endogenous substrate of ACE partly explains the antifibrotic benefits of ACE inhibitors. Phase 1 human data exists from hematopoietic studies (Goralatide/Seraspenide).