What is the half-life of AOD-9604?

AOD-9604 has a half-life of ~30 minutes, which is why it's typically administered once daily, fasted for optimal therapeutic effect.

How do I reconstitute AOD-9604?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Phase 2

AOD-9604

Also known as: AOD9604, Anti-Obesity Drug 9604, Tyr-hGH Fragment 177-191

Overview

Key Facts

Primary Goal: A modified fragment of human growth hormone (amino acids 177-191) with an added tyrosine at the N-terminus

A modified fragment of human growth hormone (amino acids 177-191) with an added tyrosine at the N-terminus. It was developed to isolate the fat-metabolizing activity of GH without its growth-promoting or diabetogenic effects. Half-Life ~30 minutes Typical Dose 250–500 mcg Frequency once daily, fasted Cycle Length 12-24 weeks

Dosing Information

Half-Life

~30 minutes

Typical Dose

250–500 mcg

Frequency

once daily, fasted

Cycle Length

12-24 weeks

Administration Routes:

subcutaneousoral

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Phase 2

AOD-9604 underwent Phase II clinical trials for obesity showing modest but statistically significant fat loss compared to placebo. It received GRAS (Generally Recognized as Safe) status from the FDA in 2014 for use as a food substance. Recent research has pivoted toward its potential in cartilage regeneration and osteoarthritis treatment.