What is the half-life of CJC-1295 (no DAC) / Mod GRF 1-29?

CJC-1295 (no DAC) / Mod GRF 1-29 has a half-life of ~30 minutes, which is why it's typically administered 1-3 times daily for optimal therapeutic effect.

How do I reconstitute CJC-1295 (no DAC) / Mod GRF 1-29?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Preclinical

CJC-1295 (no DAC) / Mod GRF 1-29

Also known as: Mod GRF 1-29, CJC-1295 without DAC, Modified GRF

Overview

Key Facts

Primary Goal: A short-acting GHRH analog with four amino acid substitutions that protect it from enzymatic degradation, resulting in a half-life of approximately 30 minutes

A short-acting GHRH analog with four amino acid substitutions that protect it from enzymatic degradation, resulting in a half-life of approximately 30 minutes. It produces acute GH pulses that more closely mimic natural physiology. Half-Life ~30 minutes Typical Dose 100–300 mcg Frequency 1-3 times daily Cycle Length 8-16 weeks

Dosing Information

Half-Life

~30 minutes

Typical Dose

100–300 mcg

Frequency

1-3 times daily

Cycle Length

8-16 weeks

Administration Routes:

subcutaneous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Preclinical

Mod GRF 1-29 has been shown to produce significant acute GH pulses comparable to native GHRH but with improved metabolic stability. When combined with GHRPs such as ipamorelin, studies show synergistic GH release that can exceed either compound alone by 2-3 fold. It is one of the most commonly used GHRH analogs in peptide research.