What is the half-life of Epitalon?

Epitalon has a half-life of ~2-3 hours, which is why it's typically administered Once daily for 10-20 day cycles for optimal therapeutic effect.

How do I reconstitute Epitalon?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

Epitalon

Also known as: Epithalon, Epithalone, AGAG, Ala-Glu-Asp-Gly

Overview

Key Facts

Primary Goal: A synthetic tetrapeptide based on the natural peptide epithalamin produced by the pineal gland

A synthetic tetrapeptide based on the natural peptide epithalamin produced by the pineal gland. While primarily known as an anti-aging peptide through telomerase activation, Epitalon plays a significant role in sleep regulation by normalizing melatonin production from the pineal gland, which declines with age. This makes it particularly valuable for age-related sleep disturbances and circadian rhythm dysregulation. Half-Life ~2-3 hours Typical Dose 5–10 mg Frequency Once daily for 10-20 day cycles Cycle Length 10-20 days on, 4-6 months off

Dosing Information

Half-Life

~2-3 hours

Typical Dose

5–10 mg

Frequency

Once daily for 10-20 day cycles

Cycle Length

10-20 days on, 4-6 months off

Administration Routes:

subcutaneousintramuscular

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Preclinical

Developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. A key study in elderly patients (ages 60-80) demonstrated that Epitalon restored evening melatonin peaks to levels resembling those of younger adults, with corresponding improvements in sleep quality and daytime alertness. The 15-year longitudinal study showed improved immune function, cardiovascular health, and endocrine balance alongside the sleep benefits. Its dual role in melatonin restoration and telomere elongation makes it uniquely positioned among sleep-supportive peptides.