What is the half-life of Fragment 176-191?

Fragment 176-191 has a half-life of 15-20 minutes, which is why it's typically administered 1-2 times daily, fasted for optimal therapeutic effect.

How do I reconstitute Fragment 176-191?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Preclinical

Fragment 176-191

Also known as: HGH Fragment 176-191, HGH Frag, GH Frag

Overview

Key Facts

Primary Goal: The C-terminal fragment of human growth hormone representing amino acids 176-191

The C-terminal fragment of human growth hormone representing amino acids 176-191. This region is responsible for the fat-metabolizing properties of GH and has been shown to promote lipolysis without the anabolic or diabetogenic effects of full-length GH. Half-Life 15-20 minutes Typical Dose 250–500 mcg Frequency 1-2 times daily, fasted Cycle Length 8-16 weeks

Dosing Information

Half-Life

15-20 minutes

Typical Dose

250–500 mcg

Frequency

1-2 times daily, fasted

Cycle Length

8-16 weeks

Administration Routes:

subcutaneous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Preclinical

HGH Fragment 176-191 was identified through structure-function studies of growth hormone that mapped the lipolytic activity to the C-terminal region. In vitro and animal studies demonstrate it promotes fat oxidation at a rate 12.5 times greater than unmodified GH without affecting carbohydrate metabolism. It is primarily used in research settings focused on obesity and metabolic syndrome.