What is the half-life of Ipamorelin?

Ipamorelin has a half-life of ~2 hours, which is why it's typically administered Once daily, 30-60 minutes before bedtime for optimal therapeutic effect.

How do I reconstitute Ipamorelin?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Phase 2

Ipamorelin

Also known as: Ipamorelin Acetate, IPA, NNC 26-0161

Overview

Key Facts

Primary Goal: A highly selective growth hormone secretagogue that stimulates GH release from the pituitary via the ghrelin receptor (GHS-R1a)

A highly selective growth hormone secretagogue that stimulates GH release from the pituitary via the ghrelin receptor (GHS-R1a). Ipamorelin is particularly relevant to sleep because the largest natural GH pulse occurs during deep slow-wave sleep. By amplifying this pulse when administered before bedtime, Ipamorelin enhances sleep quality, promotes overnight recovery, and deepens restorative sleep phases — all without significantly affecting cortisol or prolactin levels. Half-Life ~2 hours Typical Dose 100–300 mcg Frequency Once daily, 30-60 minutes before bedtime Cycle Length 8-12 weeks on, 4 weeks off

Dosing Information

Half-Life

~2 hours

Typical Dose

100–300 mcg

Frequency

Once daily, 30-60 minutes before bedtime

Cycle Length

8-12 weeks on, 4 weeks off

Administration Routes:

subcutaneous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Phase 2

Ipamorelin was developed by Novo Nordisk and has been studied in multiple Phase 1 and Phase 2 trials. A key study demonstrated dose-dependent GH release with remarkable selectivity — no significant changes in ACTH, cortisol, prolactin, or TSH at effective GH-releasing doses. Clinical trials for mail-surgical ileus (bowel recovery) used IV administration successfully. Sleep-specific research shows that GH secretagogues administered before bedtime increase slow-wave sleep duration by 20-50% in both young and older adults. Ipamorelin's clean side-effect profile makes it the preferred GH peptide for sleep optimization among researchers and clinicians.