What is the half-life of KPV?

KPV has a half-life of ~30 minutes, which is why it's typically administered 1-2x daily for optimal therapeutic effect.

How do I reconstitute KPV?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

KPV

Also known as: KPV Tripeptide, Alpha-MSH Fragment 11-13

Overview

Key Facts

Primary Goal: A tripeptide derived from the C-terminal end of alpha-melanocyte stimulating hormone (α-MSH)

A tripeptide derived from the C-terminal end of alpha-melanocyte stimulating hormone (α-MSH). Possesses potent anti-inflammatory properties without the melanogenic effects of the parent hormone. Half-Life ~30 minutes Typical Dose 200–500 mcg Frequency 1-2x daily Cycle Length 4-12 weeks

Dosing Information

Half-Life

~30 minutes

Typical Dose

200–500 mcg

Frequency

1-2x daily

Cycle Length

4-12 weeks

Administration Routes:

subcutaneousoraltopical

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2 weeks

Research Summary

Preclinical

Studied primarily in preclinical models of colitis, skin inflammation, and infection. Demonstrated ability to reduce intestinal inflammation in IBD mouse models comparable to standard treatments. Strong in vitro evidence for NF-kB pathway inhibition.