What is the half-life of KPV?

KPV has a half-life of ~30 minutes, which is why it's typically administered 1-2x daily for optimal therapeutic effect.

How do I reconstitute KPV?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

KPV

Also known as: KPV Tripeptide, Alpha-MSH Fragment 11-13

Overview

Key Facts

Primary Goal: A tripeptide fragment from the C-terminus of alpha-melanocyte stimulating hormone (alpha-MSH)

A tripeptide fragment from the C-terminus of alpha-melanocyte stimulating hormone (alpha-MSH). Possesses potent anti-inflammatory and antimicrobial properties without melanogenic effects. Particularly relevant for immune regulation in gut and mucosal tissues. Half-Life ~30 minutes Typical Dose 200–500 mcg Frequency 1-2x daily Cycle Length 4-12 weeks

Dosing Information

Half-Life

~30 minutes

Typical Dose

200–500 mcg

Frequency

1-2x daily

Cycle Length

4-12 weeks

Administration Routes:

subcutaneousoraltopical

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2 weeks

Research Summary

Preclinical

Studied in preclinical models of inflammatory bowel disease, colitis, and skin inflammation. Demonstrated efficacy comparable to standard anti-inflammatory treatments in murine IBD models. Strong in vitro evidence for NF-kB inhibition. Cross-reference: see kpv in healing-recovery for tissue repair context.