What is the half-life of Lenomorelin (Anamorelin)?

Lenomorelin (Anamorelin) has a half-life of 7-12 hours, which is why it's typically administered once daily, fasted for optimal therapeutic effect.

How do I reconstitute Lenomorelin (Anamorelin)?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Phase 3

Lenomorelin (Anamorelin)

Also known as: Anamorelin, ONO-7643, RC-1291, Adlumiz

Overview

Key Facts

Primary Goal: An orally active ghrelin receptor agonist developed primarily for cancer-related anorexia and cachexia

An orally active ghrelin receptor agonist developed primarily for cancer-related anorexia and cachexia. It stimulates appetite and increases GH secretion through selective ghrelin mimicry, and has received regulatory approval in Japan. Half-Life 7-12 hours Typical Dose 50–100 mg Frequency once daily, fasted Cycle Length 12-24 weeks (as studied in clinical trials)

Dosing Information

Half-Life

7-12 hours

Typical Dose

50–100 mg

Frequency

once daily, fasted

Cycle Length

12-24 weeks (as studied in clinical trials)

Administration Routes:

oral

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Research Summary

Phase 3

Anamorelin completed multiple Phase III trials (ROMANA 1, 2, and 3) demonstrating significant increases in lean body mass and body weight in patients with non-small cell lung cancer cachexia. It was approved in Japan in 2021 under the brand name Adlumiz. FDA approval was not pursued after the EMA declined authorization citing improvements in lean mass but insufficient evidence for functional improvement.