What is the half-life of MOTS-c?

MOTS-c has a half-life of ~4-6 hours (estimated), which is why it's typically administered 3-5 times per week for optimal therapeutic effect.

How do I reconstitute MOTS-c?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Anti-Ageing

Preclinical

MOTS-c

Also known as: MOTS-c peptide, Mitochondrial-Derived Peptide

Overview

Key Facts

Primary Goal: A mitochondrial-derived peptide encoded in the 12S rRNA gene that acts as a metabolic regulator

A mitochondrial-derived peptide encoded in the 12S rRNA gene that acts as a metabolic regulator. MOTS-c activates AMPK signaling, enhances glucose metabolism, and improves exercise capacity, positioning it as a novel approach to metabolic health and weight management. Half-Life ~4-6 hours (estimated) Typical Dose 5–10 mg Frequency 3-5 times per week Cycle Length 4-8 weeks on, 4 weeks off

Dosing Information

Half-Life

~4-6 hours (estimated)

Typical Dose

5–10 mg

Frequency

3-5 times per week

Cycle Length

4-8 weeks on, 4 weeks off

Administration Routes:

subcutaneousintravenous

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Preclinical

Discovered by Dr. Pinchas Cohen's lab at USC, MOTS-c has shown in animal studies to improve metabolic homeostasis, enhance exercise capacity, and protect against age-related metabolic decline. It activates AMPK in skeletal muscle, promoting glucose metabolism. Human observational studies correlate higher endogenous MOTS-c levels with better metabolic health. Clinical trials in humans are still in early stages.