What is the half-life of Palmitoyl Tripeptide-1?

Palmitoyl Tripeptide-1 has a half-life of ~3-5 hours (topical bioactivity window), which is why it's typically administered Twice daily (topical application) for optimal therapeutic effect.

How do I reconstitute Palmitoyl Tripeptide-1?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Preclinical

Palmitoyl Tripeptide-1

Also known as: Pal-GHK, Biopeptide-CL, Palmitoyl Oligopeptide

Overview

Key Facts

Primary Goal: A lipopeptide consisting of the GHK (Gly-His-Lys) sequence attached to a palmitoyl fatty acid chain

A lipopeptide consisting of the GHK (Gly-His-Lys) sequence attached to a palmitoyl fatty acid chain. It mimics the body's own collagen-repair signaling by acting as a matrikine — a fragment of extracellular matrix proteins that signals fibroblasts to produce new collagen. Often combined with Palmitoyl Tetrapeptide-7 in commercial formulations (marketed as Matrixyl 3000). Half-Life ~3-5 hours (topical bioactivity window) Typical Dose 2–5 mg Frequency Twice daily (topical application) Cycle Length Continuous daily use; visible results at 8-12 weeks

Dosing Information

Half-Life

~3-5 hours (topical bioactivity window)

Typical Dose

2–5 mg

Frequency

Twice daily (topical application)

Cycle Length

Continuous daily use; visible results at 8-12 weeks

Administration Routes:

topical

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Research Summary

Preclinical

Palmitoyl Tripeptide-1 was developed as a biomimetic signaling peptide based on the naturally occurring GHK sequence. In vitro studies demonstrated significant upregulation of collagen I and III synthesis in human dermal fibroblasts. When combined with Palmitoyl Tetrapeptide-7 (as Matrixyl 3000, developed by Sederma), clinical studies showed synergistic wrinkle reduction superior to either peptide alone. A 12-week study demonstrated up to 44% reduction in wrinkle volume. It is widely incorporated in premium anti-aging skincare products.