What is the half-life of Pentosan Polysulfate (PPS)?

Pentosan Polysulfate (PPS) has a half-life of ~20 hours (oral), which is why it's typically administered Oral: 3x daily; Injectable: 1x weekly for optimal therapeutic effect.

How do I reconstitute Pentosan Polysulfate (PPS)?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Healing & Recovery

Approved

Pentosan Polysulfate (PPS)

Also known as: PPS, Elmiron, Cartrophen, NaPPS

Overview

Key Facts

Primary Goal: A semi-synthetic polysulfated xylan derived from beechwood hemicellulose

A semi-synthetic polysulfated xylan derived from beechwood hemicellulose. FDA-approved for interstitial cystitis and widely used in veterinary medicine for osteoarthritis. Promotes joint recovery and cartilage protection. Half-Life ~20 hours (oral) Typical Dose 100–300 mg Frequency Oral: 3x daily; Injectable: 1x weekly Cycle Length 8-16 weeks minimum

Dosing Information

Half-Life

~20 hours (oral)

Typical Dose

100–300 mg

Frequency

Oral: 3x daily; Injectable: 1x weekly

Cycle Length

8-16 weeks minimum

Administration Routes:

subcutaneousintramuscularoral

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Research Summary

Approved

FDA-approved as Elmiron for interstitial cystitis since 1996. Extensive veterinary use (Cartrophen Vet) for osteoarthritis in dogs and horses with strong efficacy data. Mail-marketing surveillance identified rare maculopathy risk with prolonged use prompting FDA label update in 2020.