What is the half-life of Pinealon?

Pinealon has a half-life of ~1-2 hours, which is why it's typically administered Once daily for 10-15 day cycles for optimal therapeutic effect.

How do I reconstitute Pinealon?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Anti-Ageing

Preclinical

Pinealon

Also known as: EDR peptide, Glu-Asp-Arg, Brain Bioregulator

Overview

Key Facts

Primary Goal: A short bioregulator tripeptide (Glu-Asp-Arg) that specifically targets brain tissue, developed as part of the Khavinson peptide bioregulation program

A short bioregulator tripeptide (Glu-Asp-Arg) that specifically targets brain tissue, developed as part of the Khavinson peptide bioregulation program. Pinealon penetrates the blood-brain barrier and has demonstrated neuroprotective, cognitive-enhancing, and anti-aging effects on central nervous system tissues in preclinical studies. Half-Life ~1-2 hours Typical Dose 5–10 mg Frequency Once daily for 10-15 day cycles Cycle Length 10-15 days on, 3-6 months off

Dosing Information

Half-Life

~1-2 hours

Typical Dose

5–10 mg

Frequency

Once daily for 10-15 day cycles

Cycle Length

10-15 days on, 3-6 months off

Administration Routes:

subcutaneousoral

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Research Summary

Preclinical

Preclinical studies have demonstrated that Pinealon protects neurons from hypoxia-induced and oxidative damage, promoting cell survival in cortical neuron cultures. Gene expression studies show modulation of apoptosis-related genes and antioxidant enzymes. In aged animal models, Pinealon courses improved learning, memory, and neuronal density. Part of the Khavinson bioregulator program that has produced over 200 publications on short peptide bioregulation. No large-scale Western clinical trials to date.