What is the half-life of Semaglutide?

Semaglutide has a half-life of ~7 days, which is why it's typically administered Once weekly for optimal therapeutic effect.

How do I reconstitute Semaglutide?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Approved

Semaglutide

Also known as: Ozempic, Wegovy, GLP-1

Overview

Key Facts

Primary Goal: A GLP-1 receptor agonist originally developed for type 2 diabetes that has become the leading FDA-approved medication for chronic weight management

A GLP-1 receptor agonist originally developed for type 2 diabetes that has become the leading FDA-approved medication for chronic weight management. Semaglutide mimics the incretin hormone GLP-1, reducing appetite, slowing gastric emptying, and improving glycemic control. Half-Life ~7 days Typical Dose 0.25–2.4 mg Frequency Once weekly Cycle Length Ongoing / indefinite under medical supervision

Dosing Information

Half-Life

~7 days

Typical Dose

0.25–2.4 mg

Frequency

Once weekly

Cycle Length

Ongoing / indefinite under medical supervision

Administration Routes:

subcutaneousoral

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Research Summary

Approved

The STEP clinical trial program demonstrated that semaglutide 2.4 mg weekly produces an average weight loss of approximately 15% of body weight over 68 weeks. The SELECT trial further showed a 20% reduction in major adverse cardiovascular events. FDA-approved for chronic weight management in adults with BMI ≥30 or ≥27 with at least one weight-related comorbidity.