What is the half-life of SLU-PP-332?

SLU-PP-332 has a half-life of ~4-6 hours (estimated from animal pharmacokinetic data), which is why it's typically administered Once daily (research dosing, not established for humans) for optimal therapeutic effect.

How do I reconstitute SLU-PP-332?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Growth Hormone

Preclinical

SLU-PP-332

Also known as: SLUPP332, SLU PP 332, ERRγ agonist, exercise mimetic

Overview

Key Facts

Primary Goal: A synthetic small molecule agonist of estrogen-related receptor gamma (ERRγ) developed at Saint Louis University

A synthetic small molecule agonist of estrogen-related receptor gamma (ERRγ) developed at Saint Louis University. SLU-PP-332 mimics the metabolic effects of exercise by activating the same nuclear receptor pathways that are upregulated during physical activity, enhancing oxidative metabolism in skeletal muscle and promoting a shift toward fatigue-resistant muscle fiber types without actual exercise. Half-Life ~4-6 hours (estimated from animal pharmacokinetic data) Typical Dose 10–50 mg Frequency Once daily (research dosing, not established for humans) Cycle Length 4-8 weeks (based on animal study durations)

Dosing Information

Half-Life

~4-6 hours (estimated from animal pharmacokinetic data)

Typical Dose

10–50 mg

Frequency

Once daily (research dosing, not established for humans)

Cycle Length

4-8 weeks (based on animal study durations)

Administration Routes:

subcutaneousoral

Storage & Reconstitution

Unreconstituted (Powder)

Temperature2–8°C (36–46°F) or -20°C (-4°F) for long-term

DurationUp to 3 months

Reconstituted (Mixed)

Temperature2–8°C (36–46°F)

Duration2-4 weeks

Note: Protect from light. Do not freeze reconstituted solution.

Research Summary

Preclinical

Developed by Dr. Thomas Bhurrows lab at Saint Louis University, SLU-PP-332 was published in 2023 showing it activates ERRγ to replicate key metabolic benefits of exercise in mouse models. Treated mice showed increased slow-twitch muscle fibers, enhanced endurance capacity, and resistance to diet-induced obesity without changes in physical activity. The compound represents a new class of exercise mimetics targeting nuclear hormone receptors rather than traditional peptide pathways. Still in early preclinical stages with no human clinical trials initiated.