What is the half-life of SNAP-8?

SNAP-8 has a half-life of ~4-6 hours (topical activity duration), which is why it's typically administered Twice daily (topical application) for optimal therapeutic effect.

How do I reconstitute SNAP-8?

Add bacteriostatic water to the peptide vial slowly down the side. Typical reconstitution uses 2-3ml of water for a 5mg vial. Gently swirl, do not shake.

Anti-Ageing

Preclinical

SNAP-8

Also known as: Acetyl Octapeptide-3, SNAP8, Anti-Wrinkle Peptide

Overview

Key Facts

Primary Goal: A synthetic octapeptide that mimics the N-terminal end of SNAP-25, a key protein in the SNARE complex responsible for neurotransmitter release

A synthetic octapeptide that mimics the N-terminal end of SNAP-25, a key protein in the SNARE complex responsible for neurotransmitter release. By competing with native SNAP-25, SNAP-8 reduces the exocytosis of neurotransmitters at the neuromuscular junction, resulting in decreased muscle contraction and reduced expression lines — often called a 'topical Botox alternative.' Half-Life ~4-6 hours (topical activity duration) Typical Dose 3–10 mg Frequency Twice daily (topical application) Cycle Length Continuous use; visible results in 4-8 weeks

Dosing Information

Half-Life

~4-6 hours (topical activity duration)

Typical Dose

3–10 mg

Frequency

Twice daily (topical application)

Cycle Length

Continuous use; visible results in 4-8 weeks

Administration Routes:

topical

Storage & Reconstitution

Unreconstituted (Powder)

Temperature15–25°C (59–77°F)

DurationUp to 3 months

Reconstituted (Mixed)

Temperature15–25°C (59–77°F)

Duration2-4 weeks

Research Summary

Preclinical

Developed by Lipotec (now part of Lubrizol), SNAP-8 has been shown in in vitro studies to reduce SNARE complex formation by up to 40%. Clinical studies on volunteers demonstrated a 63% reduction in wrinkle depth after 28 days of twice-daily application at 10% concentration. It is an extension of the argireline (Acetyl Hexapeptide-3) concept with two additional amino acids for improved efficacy. Widely used in premium cosmeceutical formulations globally, though it does not replace neurotoxin injections for deep wrinkles.